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Lack of sleep can negatively impact your immune system. The less sleep you get, the higher your chances are of contracting the cold and flu. According to Mayo Clinic, “During sleep, your immune system releases proteins called cytokines, some of which help promote sleep. Certain cytokines need to increase when you have an infection or inflammation, or when you're under stress. Sleep deprivation may decrease production of these protective cytokines. In addition, infection-fighting antibodies and cells are reduced during periods when you don't get enough sleep. So, your body needs sleep to fight infectious diseases.”