This may be an obvious one but it’s worth repeating. Drinking more than suggested by health experts increases the risk of cancer, heart conditions and strokes. According to the CDC, excessive drinking led to approximately 88,000 deaths each year in the U.S. alone between 2006 and 2010, shortening the lives of those who died by an average of 30 years. A lot of alcohol in you system over a long period of time affects how your body absorbs calcium and deters enzymes in the liver from functioning properly.