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Don’t think “Oh, I have huge thighs, I wish they were smaller.” Bigger thighs may actually protect against premature death or heart disease. A British study says thighs that measure about 24 inches are characteristic of healthy men and women, while thinner thighs were associated with higher risks of heart conditions. The reason may be that a chunkier thigh has more muscle, which results in better regulation of the metabolism and insulin levels.