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The irritation to the nerves over time kills them eventually, Doherty says. “You first feel pins, needles and pain. Then it stops hurting and you think that’s a good sign when, in fact, it’s the opposite.” Lack of blood going to organs that are away from the heart can lead to amputation, she adds. Check with your doctor if you are at risk of diabetes and notice redness or blisters in your feet.