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If you’re on little sleep, the fat cells’ ability to react properly to insulin (the hormone that regulates energy storage) decreases by 30 percent.  Such chronic disruption could cause weight gain, type 2 diabetes and other health problems, according to a study. In storage mode, fat cells remove fatty acids and lipids from the circulation where they can damage other tissues. When fat cells cannot respond effectively to insulin, lipids leak out into circulating blood, leading to serious complications, according to researchers.