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Any changes on your skin, especially in the size or color of a mole, growth, or spot, or a new growth, even if it has no color, can be a sign of skin cancer, the American Cancer Society warns. Other symptoms include scaliness, roughness, oozing, bleeding, or a changes in the way an area of the skin looks; a sore that doesn’t heal; the spreading of pigment beyond its border, such as dark coloring that spreads past the edge of a mole or mark; and a change in sensation, such as itchiness, tenderness, or pain.