U. S. Highway 61 between Memphis and Vicksburg is famously known as the “blues highway” and it ranks up there with Route 66 as one of the most iconic roads in American music lore. Dozens of blues artists have recorded songs about Highway 61. The original route, now called Old Highway 61, was just west of here, according to Mississippi Blues Trail. This trip made our list of Underrated Road Trips You've Never Thought to Take (But Should!).