Syracuse is the big surprise on the list, moving up 17 spots in a year to make the Top 3 worst cities for allergies. The city received very high pollen scores. “The blankets of snow we have had in the past enrich the ground to provide more moisture to have increased fungal growth and mold spore release,” Dr. Borczuk says. “It also enriches other pollen growth.” Syracuse is the worst place for allergies in the Northeast.