Try to stick to the same sleep-wake schedule even when you don’t have to get up early for work. Getting up at 6 a.m. every day, and then suddenly sleeping until 1 p.m. on weekends, disrupts the body’s internal clock. “The time you wake up determines the ability to fall asleep at night,” Dr. Doghramji says. If you wake up late, falling asleep may be a problem. The bigger the difference in shut-eye time, the more jetlag symptoms you’ll experience.