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For those who suffer from asthma, Schreiber advised against activities that require long bouts of endurance. The constant, heavy breathing necessary to sustain such activities tends to dry out and irritate the airways. That said, as Mark Holbreich, M.D., an Indianapolis-based allergist, pointed out to Healthan activity like long-distance running, especially if you really enjoy it, isn’t entirely out of the question. You just need to work with your doctor to make sure you’re being treated properly and effectively.